Librería Portfolio

The bestselling introduction to bioinformatics and genomics - now in its third edition

Widely received in its previous editions, Bioinformatics and Functional Genomics offers the most broad-based introduction to this explosive new discipline. Now in a thoroughly updated and expanded third edition, it continues to be the go-to source for students and professionals involved in biomedical research.

This book provides up-to-the-minute coverage of the fields of bioinformatics and genomics. Features new to this edition include:

Extensive revisions and a slight reorder of chapters for a more effective organization
A brand new chapter on next-generation sequencing
An expanded companion website, also updated as and when new information becomes available
Greater emphasis on a computational approach, with clear guidance of how software tools work and introductions to the use of command-line tools such as software for next-generation sequence analysis, the R programming language, and NCBI search utilities
The book is complemented by lavish illustrations and more than 500 figures and tables - many newly-created for the third edition to enhance clarity and understanding. Each chapter includes learning objectives, a problem set, pitfalls section, boxes explaining key techniques and mathematics/statistics principles, a summary, recommended reading, and a list of freely available software. Readers may visit a related Web page for supplemental information such as PowerPoints and audiovisual files of lectures, and videocasts of how to perform many basic operations: www.wiley.com/go/pevsnerbioinformatics.

Bioinformatics and Functional Genomics, Third Edition serves as an excellent single-source textbook for advanced undergraduate and beginning graduate-level courses in the biological sciences and computer sciences. It is also an indispensable resource for biologists in a broad variety of disciplines who use the tools of bioinformatics and genomics to study particular research problems; bioinformaticists and computer scientists who develop computer algorithms and databases; and medical researchers and clinicians who want to understand the genomic basis of viral, bacterial, parasitic, or other diseases.



Table of Contents

Part I Analyzing DNA RNA and Protein Sequences

1 Introduction 3

2 Access to Sequence Data and Related Information 19

3 Pairwise Sequence Alignment 69

4 Basic Local Alignment Search Tool (BLAST) 121

5 Advanced Database Searching 167

6 Multiple Sequence Alignment 205

7 Molecular Phylogeny and Evolution 245

Part II Genomewide Analysis of DNA RNA and Protein

8 DNA: The Eukaryotic Chromosome 307

9 Analysis of Next-Generation Sequence Data 377

10 Bioinformatic Approaches to Ribonucleic Acid (RNA) 433

11 Gene Expression: Microarray and RNA-seq Data Analysis 479

12 Protein Analysis and Proteomics 539

13 Protein Structure 589

14 Functional Genomics 635

Part III Genome Analysis

15 Genomes Across the Tree of Life 699

16 Completed Genomes: Viruses 755

17 Completed Genomes: Bacteria and Archaea 797

18 Eukaryotic Genomes: Fungi 847

19 Eukaryotic Genomes: From Parasites to Primates 887

20 Human Genome 957

21 Human Disease 1011

GLOSSARY 1075

Self-Test Quiz: Solutions 1103

Author Index 1105

Subject Index 1109