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The revised edition of this renowned and bestselling title is the most comprehensive single text on all aspects of biomaterials science. It provides a balanced, insightful approach to both the learning of the science and technology of biomaterials and acts as the key reference for practitioners who are involved in the applications of materials in medicine.

Key Features
Over 29,000 copies sold, this is the most comprehensive coverage of principles and applications of all classes of biomaterials: ´the only such text that currently covers this area comprehensively´ - Materials Today
Edited by four of the best-known figures in the biomaterials field today; fully endorsed and supported by the Society for Biomaterials
Fully revised and expanded, key new topics include of tissue engineering, drug delivery systems, and new clinical applications, with new teaching and learning material throughout, case studies and a downloadable image bank



Table of Contents
Contributors

Preface

How to Use this Book

Introduction: Biomaterials Science: An Evolving, Multidisciplinary Endeavor

Biomaterials and Biomaterials Science

Key Definitions

The Evolution of the Biomaterials Field

Examples of Today's Biomaterials Applications

Characteristics of Biomaterials Science

Subjects Integral to Biomaterials Science

Biomaterials Literature

Biomaterials Societies

Summary

A History of Biomaterials

Biomaterials before World War II

World War II to the Modern Era: The Surgeon/Physician Hero

Designed Biomaterials

The Contemporary Era (Modern Biology and Modern Materials)

Conclusions

Part 1: Materials Science and Engineering

Section I.1: Properties of Materials

Chapter I.1.1. Introduction: Properties of Materials: The Palette of the Biomaterials Engineer

Chapter I.1.2. The Nature of Matter and Materials

Introduction

Atoms and Molecules

Molecular Assemblies

Surfaces

Conclusion

Bibliography

Chapter I.1.3. Bulk Properties of Materials

Introduction

Load, Nominal Stress, Extension, and Nominal Strain

True Stress and True Strain

Shear Stress and Shear Strain

Bulk Mechanical Properties Determined from Stress-Strain Plots

Other Bulk Properties

Worked Example

bibliography

Chapter I.1.4. Finite Element Analysis in Biomechanics

Introduction

Overview of the Finite Element Method

Conclusion

Bibliography

Chapter I.1.5. Surface Properties and Surface Characterization of Biomaterials

Introduction

Surface Analysis Techniques: Principles and Methods

Studies with Surface Methods

Conclusions

Acknowledgment

Bibliography

Chapter I.1.6. Role of Water in Biomaterials

Water: The Special Molecule

Water: Structure

Water: Significance for Biomaterials

Bibliography

Section I.2: Classes of Materials Used in Medicine

Chapter I.2.1. Introduction: The Diversity and Versatility of Biomaterials

Chapter I.2.2. Polymers: Basic Principles

Introduction

The Polymer Molecule

Molecular Weight

Connecting Physical Behavior with Chemical Characteristics

Polymer Synthesis

Case Studies

The Present and The Future

Bibliography

A. Polyurethanes

Introduction

Anatomy of a Polyurethane Molecule

The Physical Properties of Polyurethanes

Polyurethane Synthesis

Concluding Remarks

Bibliography

B. Silicones

Chemical Structure and Nomenclature

Conclusion

Acknowledgments

Bibliography

C. Fluorinated Biomaterials

Introduction

Interesting Fluoropolymer Chemical and Physical Properties Derived from their Polymer Chemistry, Molecular Structure, and Bonding

Distinguishing the Different Fluoropolymers

Biomedical Applications

Summary

Glossary

Bibliography

D. Acrylics

Introduction

Mono- and Multi-Methacrylate Monomers

Summary

Acknowledgments

Bibliography

Chapter i.2.3. Metals: Basic Principles

Introduction

Steps in the Fabrication of Metallic Biomaterials

Microstructures and Properties of Implant Metals

Concluding Remarks

Bibliography

A. Titanium and Nitinol (NiTi)

Fabrication

Corrosion Resistance

Biocompatibility and Surface Modification

Mechanical Properties

NiTi Alloy

Surface Modifications of NiTi

Applications

Bibliography

B. Stainless Steels

Introduction

Metallurgical and Chemical Considerations

Mechanical Properties

Corrosion Behavior

Summary

Bibliography

Chapter I.2.4. Ceramics, Glasses, and Glass-Ceramics: Basic Principles

Types of Bioceramics: Tissue Attachment

Characteristics and Processing of Bioceramics

Nearly Inert Crystalline Ceramics

Porous Ceramics

Bioactive Glasses and Glass-Ceramics

Bioactivity Reaction Stages

Calcium Phosphate Ceramics

Calcium Phosphate Coatings

Calcium Phosphate Implants: Mechanical Properties and Porosity

Resorbable Calcium Phosphates

Calcium Phosphate Bone Cements

Clinical Applications of HA

References

A. Natural and Synthetic Hydroxyapatites

Introduction

Applications of Hap Ceramics

Synthesis of Hap Ceramics

Structure Characterization of Hap Ceramics

Stability, Biocompatibility, and Osteointegration of Hap Ceramics

References

B. Alumina

Introduction

Production of Alumina

Structure of Alumina

Properties of Alumina

Alumina as a Biomaterial

Alumina in Joint Replacements

Alumina in Bone Spacers

Alumina in Dental Applications

Other Applications of Alumina

Alumina Matrix Composites

Conclusion

Bibliography

Chapter I.2.5. Hydrogels

Introduction

Classification and Basic Structures Of Hydrogels

Synthesis of Hydrogels

Swelling Behavior of Hydrogels

Determination of Structural Characteristics

Biomedical Hydrogels

"Smartö or "Intelligent,ö Stimuli-Responsive Hydrogels and Their Applications

Biomedical Applications of Hydrogels

Bibliography

Chapter I.2.6. Degradable and Resorbable Biomaterials

Introduction

Definitions Relating to the Processes of Degradation Versus Biodegradation, and Erosion Versus Bioerosion

Overview of Currently Available Degradable Polymers

Applications of Synthetic, Degradable Polymers as Biomaterials

Bibliography

Chapter I.2.7. Engineered Natural Materials

Introduction to Commonly Used Natural Materials

HA in Medicine: The Old and the New

Recreating the Extracellular Matrix

Meeting the Translational Challenge

Glossary of Acronyms

Disclosure Statement

bibliography

Chapter I.2.8. Pyrolytic Carbon for Long-Term Medical Implants

Introduction

Elemental Carbon

Pyrolytic Carbon (PyC)

Steps in the Fabrication of Pyrolytic Carbon Components

Biocompatibility of Pyrolytic Carbon

Clinical Applications

Conclusion

Bibliography

Chapter I.2.9. Composites

Introduction

Reinforcing Systems

Matrix Systems

Fabrication of Composites

Absorbable Matrix Composites

Non-Absorbable Matrix Compo